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University of Iowa News Release


May 1, 2008

UI study on heart attack, stroke invites participants

People age 45 and older who have had a stroke, heart attack, chest pain or heart-related surgery are invited to participate in a University of Iowa research study on preventing these conditions and related complications.

Those who experience leg pain while walking or exercising or who have had surgery to open up blocked arteries in the legs or neck may also be eligible to participate.

The study will evaluate the safety and effectiveness of the cholesterol-lowering drug simvastatin (Zocor) combined with a placebo (inactive substance) compared to the use of simvastatin combined with extended-release niacin.

Eligible participants will randomly be assigned to one of the two study groups and will be required to make up to 16 visits to the UI Lipid Research Center. The entire study will last four to six years.

Women who have the potential to become pregnant must agree to practice an effective method of birth control throughout the study.

Qualified participants will receive, at no cost, physical exams and electrocardiograms, laboratory evaluation and medication to lower cholesterol. Compensation for each visit also will be provided.

Nearly 3,300 individuals are expected to participate in this study at 90 sites in the United States and Canada. The UI portion of the study will screen up to 200 people and is led by Jennifer Robinson, M.D., associate professor of epidemiology in the UI College of Public Health and director of the UI Lipid Research Center.

This research study is funded by the National Institutes of Health, the National Heart, Lung and Blood Institute, and Abbott Laboratories.

For more information, call toll-free 800-887-6917 or locally 319-384-5046.

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 52242-1178

MEDIA CONTACTS: UI Lipid Research Center, 800-887-6917 or 319-384-5046; Becky Soglin, UI Health Science Relations, 319-335-6660,