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University of Iowa News Release


Aug. 24, 2007

Holden Comprehensive Cancer Center awards seed grant funds

Leaders with Holden Comprehensive Cancer Center at the University of Iowa today announced a $10,000 grant for cancer research to a physician who cares for patients at UI Children's Hospital.

M. Sue O'Dorisio, M.D., Ph.D., professor in the UI Department of Pediatrics, will serve as the principal investigator on a Holden Comprehensive Cancer Center Seed Grant for Translational Project Development and Clinical Trials. The grant term will be Sept. 1, 2007, through Aug. 31, 2008.

The grant provides Phase I funding for a project titled "Dual-Target, Dual-Isotope Radiotherapy in Pediatric Solid Tumors: A Pilot Dosimetry Study of 131I-MIBG and 111In-DOTA-tyr3-Octreotide." Cancers such as neuroblastoma in children and neuroendocrine tumors in adolescents will take both drugs into malignant cells simultaneously, resulting in two "hits" to each tumor cell and increasing the likelihood of killing the cancer cells. This will be the first time that these two anti-cancer agents have been used together in children or young adults.

Holden Comprehensive Cancer Center is Iowa's only National Cancer Institute (NCI)-designated comprehensive cancer center. NCI-designated comprehensive cancer centers are recognized as the leaders in developing new approaches to cancer prevention and cancer care, conducting leading-edge research and educating the public about cancer.

UI Children's Hospital serves children and their families at its main campus in Iowa City and satellite clinics in communities throughout the region. A 180-bed "hospital within a hospital," UI Children's Hospital benefits from the sophisticated services and comprehensive resources of UI Hospitals and Clinics. Child magazine ranks UI Children's Hospital among the top 20 children's hospitals in the nation.

STORY SOURCE: Joint Office for Marketing and Communications, University of Iowa Health Care, 200 Hawkins Drive, Room E110 GH, Iowa City, Iowa 52242-1009

MEDIA CONTACT: Tom Moore, 319-356-3945,