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University of Iowa News Release

June 29, 2006

UI Study To Examine Calcium, Vitamin D Effects On PMS Symptoms

The University of Iowa College of Public Health is conducting a study of calcium and vitamin D for premenstrual syndrome (PMS).

This study will determine whether taking a large dose of calcium and vitamin D for part of a menstrual cycle can effectively prevent or decrease PMS symptoms.

PMS affects millions of women during their reproductive lives. Many women experience PMS symptoms such as depression, mood swings, irritability, bloating, water retention and food cravings associated with their menstrual cycle. 

"Clinical research suggests that PMS is associated with a calcium and vitamin D deficiency state during the latter half of the menstrual cycle," said Susan Johnson, M.D., UI professor of obstetrics and gynecology and principal investigator for the study. "Previous research demonstrated that calcium supplementation can alleviate most PMS symptoms."

The study is open to women who have PMS symptoms during their menstrual cycle. Participants must be 18 to 42 years old, not using a hormonal method of birth control, and have a regular menstrual cycle of 23-34 days. 

There are a total of six study visits to the research clinic at the UI during this five-month study. All participants will receive the active study medication and a placebo (inactive pill) at different times during the three-month treatment phase. Compensation is available.

For more information call 319-384-5055 or toll free 800-348-4692.

STORY SOURCE: University of Iowa Health Science Relations, 5139 Westlawn, Iowa City, Iowa 52242-1178

MEDIA CONTACT: David Pedersen, 319-335-8032,