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University of Iowa News Release

Release: June 8, 2006

Women Age 26 And Up Invited To Take Part In Cervical Cancer Vaccine Study

Women age 26 and older are invited to participate in a University of Iowa research study to test the immune response, safety and effectiveness of an investigational vaccine for human papillomavirus (HPV) types 16 and 18. These types of HPV are associated with nearly three out of every four cases of cervical cancer.

Women interested in participating must be healthy overall and without a previous history of HPV. Volunteers also must not be pregnant or planning to conceive during the first eight months of the study, and they must be willing to make nine visits over the course of three years to the Vaccine Trials Office on the UI campus.

Participants will be chosen randomly to receive either the HPV study vaccine or a placebo (inactive) vaccine. The study vaccine has been used previously in HPV-16 and HPV-18 research studies with pre-teen and adolescent subjects.

The study includes free blood tests and gynecological exams that will test for the presence of HPV infection or precancerous cells. Compensation will be provided.

The study will enroll approximately 5,400 women from different countries. At the UI, where 100 women are expected to participate, the principal investigator is Jack Stapleton, M.D., professor of internal medicine and director of the Division of Infectious Diseases in the UI Roy J. and Lucille A. Carver College of Medicine.

For more information, contact Tracy Peters, UI research nurse, or Tobey Kelly, at 319-384-4531 or and ask about the HPV vaccine trial.

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 5224-1178

STUDY CONTACT: Tracy Peters, (319) 384-4531,

MEDIA CONTACT: Becky Soglin, 319 335-6660