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University of Iowa News Release

Release: March 12, 2003

UI Study Seeks People With Overactive Bladder

Men and women age 18 and older who have had an overactive bladder with or without urge incontinence for six or more months are invited to participate in a University of Iowa Health Care treatment study. The investigation will assess how well the medication Tolterodine extended release, compared to placebo (inactive substance), works to control symptoms of urgency and improve bladder condition.

Overactive bladder includes frequent urination and urgency, which is the strong desire to urinate for fear of urine leakage. Participating women must not be pregnant or nursing, and women of child-bearing potential will be required to use a reliable form of birth control. People with narrow-angle glaucoma are not eligible to participate.

The study will last 12 to 14 weeks and will involve five visits to UI Hospitals and Clinics in Iowa City. The first visit will include a physical examination and, for women, a pregnancy test. The second visit will include urinalysis as well as a second pregnancy test for women. At the second visit, participants will be assigned to receive either the medication or the placebo. Participants will be asked to keep weekly dairies on their voiding (urination) habits for a total of four weeks and to respond to several quality-of-life questionnaires over the study period. Compensation will be provided.

For more information, contact Mary Eno, UI research assistant in urology, at (319) 384-9265. The study's principal investigator is Karl Kreder, M.D., UI professor of urology and director of Urodynamics and Reconstructive Urology in the department.

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 5224-1178

CONTACTS: Media: Becky Soglin, 319 335-6660 Prospective Participants: Mary Eno, UI research assistant in urology, (319) 384-9265