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University of Iowa News Release

April 3, 2003

UI Study On Mildly Abnormal Pap Smears Seeks Participants

Women age 18 and older who have not gone through menopause are invited to participate in a University of Iowa Health Care study on mildly abnormal pap smears. The study will investigate the safety of a drug as a potential treatment for cervical dysplasia, which is a precancerous condition of the cervix (the entry to the birth canal).

Eligible participants must have been diagnosed with a mildly abnormal pap smear. In addition, they must not be pregnant or lactating and must be using birth control pills or Depo-Provera.

Participation includes eight visits to UI Hospitals and Clinics over a two-to three-month period. The initial screening visit involves routine blood testing, a pelvic examination (pap smear) and a physical examination. At the second visit, participants will be assigned to receive either the medication or a placebo (inactive substance). Visits two through seven will occur over a three-week period and will require overnight hospital stays, as the medication must be taken at the hospital. Participants will receive additional routine blood testing and pelvic examinations during the study period. In addition, participants must keep a daily diary to record any changes in their health. Compensation will be provided.

"Five to 15 percent of all pap smears come back with a 'mildly abnormal' reading, and currently there is no good treatment for the condition," said the study's lead investigator, Kevin A. Ault, M.D., UI assistant professor of gynecology and obstetrics.

For more information, contact Kristen Followwill, UI research assistant in obstetrics and gynecology, at (319) 356-4602 or

University of Iowa Health Care describes the partnership between the UI Roy J. and Lucille A. Carver College of Medicine and UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at

STORY SOURCE: University of Iowa Health Science Relations, 5137 Westlawn, Iowa City, Iowa 5224-1178

CONTACTS: Media: Becky Soglin, 319 335-6660 Prospective Participants: Kristen Followwill, 319-356-4602,