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Release: Feb. 7, 2002

People Invited To Participate In Blood Vessel Study

Non-smoking men and women with above normal body weight are invited to participate in a University of Iowa Health Care study on how diabetes causes blood vessel disease.

People interested in participating must fit into one of four categories:

-- Non-smoking men ages 35-70 with above normal weight but without diabetes;

-- Non-smoking women ages 37-48 with above normal weight but without diabetes;

-- Non-smoking women ages 57-67 with above normal weight but without diabetes;

-- Non-smoking men or women ages 18-85 who have type 2 diabetes.

Potential participants will be asked to come to the General Clinical Research Center at UI Hospitals and Clinics for an approximately two-hour screening visit to determine eligibility. The screening session requires pre-visit fasting for a blood test, an EKG and a physical examination. Compensation will be provided for the screening visit.

If the screening results indicate that a person is eligible for the study, that person will be asked to come in for a second, four-hour study visit that involves taking circulation measurements in the UI Human Cardiovascular Physiology Laboratory.

The study visit will take place anywhere from one to five weeks or more after the initial screening visit. Participants will be asked not to take certain medications, vitamins or supplements for a period of time before the second visit.

The second visit will include blood pressure and blood flow measurements. Participants will receive a number of drugs through a small catheter to the arm and be measured for how these drugs affect blood flow. Compensation will also be provided for this four-hour study.

The primary investigator for the study is Arna Gudmundsdottir, M.D., fellow in the UI Division of Endocrinology.

For more information, contact Diabetes Clinical Research and Programs toll-free at (877) 807-9590 or locally at 356-4879.

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at