CONTACT: GARY GALLUZZO
300 Plaza Centre One
Iowa City IA 52242
(319) 384-0009; fax (319) 384-0024
Release: Dec. 3, 2002
Research team gets $2.5 million grant to develop glucose monitor
multidisciplinary research team at the University of Iowa Optical Science
and Technology Center (OSTC) has received a four-year, $2,564,658 grant from
the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
to develop a novel blood glucose sensor for the management of diabetes.
Mark A. Arnold, (left) professor of chemistry in the University
of Iowa College of Liberal Arts and Sciences and OSTC director, says that
the objective of the interdisciplinary research program is to develop a glucose
monitor that examines a small volume of interstitial fluid continuously extracted
from under the skin. The glucose concentration of the fluid will be measured
noninvasively with a chip-based, near infrared spectrometer.
Arnold, who has been working on noninvasive, blood glucose monitoring devices
for more than 14 years, hopes to replace the current monitoring procedure,
consisting of numerous finger sticks and test-strip glucose meters, with a
beam of light to provide information on blood glucose concentrations. The
OSTC project, being conducted in the Iowa Advanced Technology Laboratories
building, will develop new materials to detect the specific wavelengths of
light absorbed by glucose.
A successful continuous glucose monitor would provide more glucose information
than is possible with conventional test-strip technology. More frequent testing,
in turn, would allow greater control of blood sugar levels, thereby reducing
the long-term medical complications caused by chronic hyperglycemia while
avoiding dangerous hypoglycemic conditions.
"An exciting feature of this project is the collaboration of 10 different
research groups from multiple colleges on campus," Arnold says. In addition
to Arnold, researchers include the following professors: John Prineas and
Michael Flatté of the department of physics and astronomy and Thomas
Boggess of physics and astronomy and the UI College of Engineering department
of electrical and computer engineering; David Andersen of the department of
electrical and computer engineering; William Sivitz of the UI Carver College
of Medicine department of internal medicine; Scott Martin of the department
of chemistry; and Chris Coretsopoulos of the department of chemistry. Also,
Gary Small of the Ohio University department of chemistry and biochemistry;
and Linda Olafsen of the University of Kansas department of physics and astronomy
are members of the research team.
Arnold adds that interdisciplinary work is necessary because, "Success
demands advances in novel semiconductor materials, photoelectronic devices,
microfluidics and chip fabrication, system controller electronics, and computer-based
data processing algorithms."