The University of Iowa
The University of Iowa News Services Home News Releases UI in the News Subscribe to UI News Contact Us


5137 Westlawn
Iowa City IA 52242
(319) 335-6660; fax (319) 384-4638

Release: Aug. 29, 2001

NOTE TO EDITORS: This release can be used anytime THROUGH NOV. 30, 2001.

Women with bladder overactivity invited to be in UI study

IOWA CITY, Iowa -- Women with certain bladder problems are invited to participate in a University of Iowa Health Care Study to test the effectiveness of a medication to alleviate the symptoms and improve quality of life.

Participants must be age 18 and older and have experienced over the past three months either bothersome urinary urgency (feeling the urgent need to void for fear of leakage) or urge urinary incontinence (the involuntary loss of urine preceded by urgency). In addition, eligible participants must have urinary frequency with an average voiding of every two hours or less, which will be confirmed at a preliminary study visit.

Women who are not eligible for the study include those already taking regular medication for urge incontinence within one month prior to the study. In addition, participants must not be taking any antidepressants and must not be pregnant or planning to get pregnant during the study period. Women on certain antianxiety drugs are eligible to participate.

Participants will be asked to make a total of six visits to the UI Hospitals and Clinics in Iowa City, including two initial evaluations that will determine whether each person fully qualifies for the study. The additional four visits will take place over a 12-week period. Half of the study participants will receive the medication, while half will receive a placebo (sugar pill). Compensation will be provided.

The study is being conducted by Karl Kreder, M.D., UI professor of urology and director of the UI Division of Urodynamics and Reconstructive Urology, and Ingrid Nygaard, M.D., UI associate professor of obstetrics and gynecology and director of the UI Urogynecology Program.

For more information contact, Mary Eno, UI research associate in urology, at (319) 384-9265 or Debra Brandt, UI research associate in gynecology, at (319) 356-1650.

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide. Visit UI Health Care online at