CONTACT: BECKY SOGLIN
2130 Medical Laboratories
Iowa City IA 52242
(319) 335-6660; fax (319) 335-8034
Release: March 29, 2000
UI Cancer Center researchers receive American Cancer Society research
IOWA CITY, Iowa -- Two University of Iowa Cancer Center researchers have
each received a $375,000 research grant from the American Cancer Society.
Mark A. Stamnes, Ph.D., UI assistant professor of physiology and biophysics
in the College of Medicine, and Zhendong Jin, Ph.D., assistant professor in
the Division of Medicinal and Natural Products Chemistry in the College of
Pharmacy, join four other UI colleagues who have active American Cancer Society
The American Cancer Society research program uses a nationwide peer review
process. Each grant is reviewed and ranked for merit by 12 to 25 senior scientists
who are experts in the field of the proposed research. Only about 8 to 10
percent of all grant applications submitted receive funding. Stamnes' and
Jin's grants are effective Jan. 1, 2000 to Dec. 31, 2002.
Stamnes will study how cells transport cellular components. To grow, cells
must add material to their surface using transport vesicles, which move cell
components from place to place and to the cell surface. In cancerous cells,
growth is not regulated. A better understanding of the transport process could
help lead to ways to diagnose and treat cancer.
Jin's research is based on Superstolide A and B, newly isolated natural
compounds that show highly potent anticancer activities. However, the scarcity
of these compounds has hampered research. Jin proposes to create synthetic
Superstolide A and B and make them available for further research. He will
also try to synthesize compounds that mimic Superstolide A and B to improve
on their natural anticancer properties and increase understanding of how they
The other UI researchers who have active American Cancer Society funding
include David M. Lubaroff, Ph.D., professor of urology; Dawn Quelle, Ph.D.,
assistant professor of pharmacology; Lori L. Wallrath, Ph.D., assistant professor
of biochemistry; and Richard D. Williams, M.D., professor and head of urology.
In addition, Richard J. Roller, Ph.D. assistant professor of microbiology,
received an American Cancer Society grant effective Jan. 1997 to Dec. 2000.
The UI Cancer Center in Iowa City is dedicated to cancer research, clinical
care, education, detection and prevention. The center advances cancer research
and education through the collaborative efforts of researchers and physicians
from 26 departments in six UI colleges and the UI Hospitals and Clinics. Using
knowledge gained through this research, UI physicians and other health care
professionals work together in the John and Mary Pappajohn Clinical Cancer
Center to provide the most advanced cancer care available in a manner that
recognizes each patient as an individual. The UI Cancer Center receives funding
from other major organizations, in addition to the American Cancer Society,
as well as from UI alumni, friends, businesses and foundations.
Since 1946, the American Cancer Society has funded more than $2.2 billion
in cancer research. American Cancer Society funding has led to many of the
important breakthroughs that have advanced early detection, prevention and
treatment techniques and strategies. In addition, the American Cancer Society
has supported 30 researchers who eventually became Nobel Prize recipients.
University of Iowa Health Care describes the partnership between the
UI College of Medicine and the UI Hospitals and Clinics and the patient care,
medical education and research programs and services they provide.