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Iowa City IA 52242
(319) 335-6660; fax (319) 335-8034

Release: Feb. 15, 2000

Note to Editors: This release was originally distributed Jan. 28. Researchers will continue to recruit study participants until March 17.

Men are invited to participate in UI urinary frequency urgency study

IOWA CITY, Iowa -- University of Iowa Health Care researchers invite men with bladder overactivity and coexisting mild to moderate bladder outlet obstruction to participate in a study of the safety and efficacy of a medication to treat the condition.

Participants must be age 40 or older and experiencing urinary frequency (averaging eight or more urinations daily) and urinary urgency or urge incontinence. Men with previous bladder or prostate surgery or instrumental treatment for prostate problems are not eligible to participate. In addition, men must not have experienced urinary retention within the past 12 months.

The study will last 12 weeks during which participants must be willing to make four visits to the UI Hospitals and Clinics and take either the study medication (tolterodine) or a placebo. Compensation will be provided.

Men who have enlarged prostates, which typically occurs with age, may experience bladder control problems, said Karl J. Kreder, M.D., UI professor of urology and lead investigator for UI participation in the study.

"The medication under investigation is designed to relax the bladder," said Kreder, who is director of the UI Urodynamics and Reconstructive Urology division.

For more information about the study, contact Mary Eno, research nurse, at (319) 384-9265.

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide.