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Release: Dec. 12, 2000

EDITORS: This release can be used anytime THROUGH JAN. 7, 2001

Study seeks men with erectile dysfunction after prostate cancer treatment

IOWA CITY, Iowa -- Men with erectile dysfunction following removal of their prostate gland for treatment of prostate cancer are invited to a participate in a University of Iowa Health Care Study to test the effectiveness of a new medication, similar to Viagra, in treating erectile dysfunction.

Participants must be age 18 and older and have their physician provide documentation that they had a nerve-sparing treatment for their prostate gland removal. Interested individuals must have had their prostate gland removed at least six months prior to beginning the study and no more than five years ago. Participants also must be in a stable, heterosexual relationship that has lasted for at least six months.

In addition, participants must not have a history of heart disease, stroke or diabetes, or have life-threatening arrhythmia or severe migraine headaches within six months prior to the study. They also must not be taking more than two medications for high blood pressure.

Participants will be asked to make a total of five monthly visits to the UI Hospitals and Clinics in Iowa City, including an initial screening for a physical exam, EKG test and blood work that will determine whether each person fully qualifies for the study. The other visits will include EKG tests, blood work, filling out quality-of-life questionnaires and reviewing the diary each patient must keep on his sexual activity.

One-third of the participants will receive a placebo (sugar pill), while all other participants will receive the study medication in one of two dosage levels. Participants also will be compensated for each visit.

The study is being led by Richard Williams, M.D., Ruben H. Flocks Chair and head of the UI Department of Urology. For more information contact, Mary Eno, UI research associate in urology, at (319) 384-9265.

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide.