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Release: Nov. 4, 1999

UI invites people to take part in type 2 diabetes study

IOWA CITY, Iowa -- University of Iowa Health Care researchers invite people with type 2 diabetes to participate in a study of diabetes and blood vessel function.

Participants must be nonsmokers, 18 to 70 years old with type 2 diabetes and no history of alcoholism or drug abuse during the past five years. Women must not be pregnant or planning to conceive while enrolled in the study, which will last approximately nine months.

Participants must be willing to take medication daily, check their blood sugar level twice daily and make a total of 10 visits to the UI Hospitals and Clinics. Compensation, study medication and blood sugar monitoring supplies will be provided.

The study will test the effectiveness of glyburide and metformin, medications approved by the Food and Drug Administration, on insulin action and secretion, and blood vessel function.

People with type 2 diabetes often have impaired blood vessel function, which causes decreased circulation. This in turn may affect the body’s ability to heal an injury or fight infection.

"Impaired blood vessel function may be a factor in the increased incidence of cardiovascular disease seen in people with type 2 diabetes," said William Sivitz, M.D., UI associate professor of internal medicine and principal investigator. "The study purpose is to determine the effect of type 2 diabetes treatment on arterial blood vessel function and certain metabolic parameters."

Sivitz is also a staff physician at the Iowa City Veterans Affairs Medical Center. The study is one of several UI clinical and basic science diabetes studies sponsored by the Veterans Affairs/Juvenile Diabetes Foundation.

For more information, call Sheila Wayson, nurse clinician and certified diabetes educator, toll-free at (877) 807-9590 or locally at (319) 356-4879 and ask about Protocol 1.

University of Iowa Health Care describes the partnership between the UI College of Medicine and the UI Hospitals and Clinics and the patient care, medical education and research programs and services they provide.