CONTACT: BECKY SOGLIN
2130 Medical Laboratories
Iowa City IA 52242
(319) 335-6660; fax (319) 335-8034
Release: Nov. 4, 1999
UI invites people to take part in type 2 diabetes study
IOWA CITY, Iowa -- University of Iowa Health Care
researchers invite people with type 2 diabetes to participate in a study of
diabetes and blood vessel function.
Participants must be nonsmokers, 18 to 70 years old
with type 2 diabetes and no history of alcoholism or drug abuse during the
past five years. Women must not be pregnant or planning to conceive while
enrolled in the study, which will last approximately nine months.
Participants must be willing to take medication daily,
check their blood sugar level twice daily and make a total of 10 visits to
the UI Hospitals and Clinics. Compensation, study medication and blood sugar
monitoring supplies will be provided.
The study will test the effectiveness of glyburide
and metformin, medications approved by the Food and Drug Administration, on
insulin action and secretion, and blood vessel function.
People with type 2 diabetes often have impaired blood
vessel function, which causes decreased circulation. This in turn may affect
the bodys ability to heal an injury or fight infection.
"Impaired blood vessel function may be a factor
in the increased incidence of cardiovascular disease seen in people with type
2 diabetes," said William Sivitz, M.D., UI associate professor of internal
medicine and principal investigator. "The study purpose is to determine
the effect of type 2 diabetes treatment on arterial blood vessel function
and certain metabolic parameters."
Sivitz is also a staff physician at the Iowa City
Veterans Affairs Medical Center. The study is one of several UI clinical and
basic science diabetes studies sponsored by the Veterans Affairs/Juvenile
For more information, call Sheila Wayson, nurse clinician
and certified diabetes educator, toll-free at (877) 807-9590 or locally at
(319) 356-4879 and ask about Protocol 1.
University of Iowa Health Care describes the partnership
between the UI College of Medicine and the UI Hospitals and Clinics and the
patient care, medical education and research programs and services they provide.