CONTACT: JENNIFER CRONIN
2130 Medical Laboratories
Iowa City IA 52242
(319) 335-5661; fax (319) 335-9917
UI researcher wins grant from the National Cancer Institute
IOWA CITY, Iowa -- Frederick Quelle, Ph.D., University of Iowa assistant
professor of pharmacology, has received a five-year National Cancer Institute
grant of more than $950,000.
Quelle's project, entitled "Cytokine Signaling Pathways Regulating
a G1 Checkpoint," started in December and will last through 2003.
His work focuses on how and why some damaged cells bypass safety checkpoints
meant to prevent tumors from developing.
"When cells suffer DNA damage, they should stop growing and repair
the DNA damage," Quelle explained. "However, sometimes these
checkpoints fail when blood cells are exposed to hormones called cytokines.
Damaged cells that do not stop growing may eventually become cancerous."
Quelle said he hopes to identify the mechanism that enables the damaged
cells to skip over the checkpoints. A UI faculty member since 1997, Quelle
has always been interested in cytokines and how they control cell growth.
Cytokines are proteins that control the growth and function of blood and